After escaping the fallout of a bioweapon, famous musician Thomas Wylde is brought to an air shelter outside of Pittsburgh with other important people, including the Pennsylvania governor. One of Thomas' bandmates falls victim to the infection, and the governor gives him an ultimatum: have his friend executed to protect the other passengers, or abandon shelter to find a lost outpost that was working on a cure. Struggling with addiction and fighting for his friend's life, Thomas must face the horrors of the outside world, along with even more interesting characters that provide new perspectives on what really went down that day.